Ayeza Khan began her career as an actress at the age of 18, making her debut with a supporting role in the romance Tum Jo Miley, that aired on Hum TV. After portraying supporting roles in several television series, she appeared as leading actress in the Geo TV romantic drama Tootey Huwey Per (2011). She later established herself as a leading actress in Pakistan with several roles in the drama Aks (2012), the romantic drama Kahi Unkahi (2012), and Adhoori Aurat (2013), the family drama Mere Meherbaan (2014), and the tragic romance Tum Kon Piya (2016), all of which garnered her wide recognition. Her performance in the 2014 social drama Pyarey Afzal earned her critical acclaim and Lux Style Award for Best Television Actress.
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Interestingly enough another actress was approached for this role as well. As per our credible sources, actress Sonya Hussain was approached for the role of Mehwish in Meray Pass Tum Ho. The Ishq Zahe Naseeb actress declined the role terming it to be highly negative portrayal of women. It seems that the actress was hesitant to do the role as it would garner a lot of backlash from the audiences, which to some extent did happen.